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Amorphous trehalose dihydrate by cryogenic milling ...

We have demonstrated that the crystal to glass transformation for trehalose dihydrate is possible using cryogenic milling. This is the first reported example of cryogenic milling (a mild and widely applicable technique) applied to generating amorphous hydrates.

Critical Considerations for the Qualitative and ...

Critical Considerations for the Qualitative and Quantitative Determination of Process-Induced Disorder in Crystalline Solids Ann Newman 1,* and George Zografi 2

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(PDF) Distinct effects of sucrose and trehalose on protein ...

Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying. European Journal of Pharmaceutical Sciences, 2006. Gerard Hofland.

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Mechanically Induced Amorphization of Drugs: A Study of ...

At higher milling rates, it is likely that most of the nuclei are forced back into the amorphous phase resulting in a fewer number of nuclei. Clearly, milling will result in the creation of a large amount of surface on the amorphous solid which can increase the extent of crystallization occurring around the glass transition temperature.

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The Amorphous Form in Drug Development - PolyCrystalline

and a dihydrate L. Yu. Amorphous Pharmaceutical Solids: preparation, characterization and stabilization. Adv. Drug Del. Rev., 2001, 27-42. Amorphous treahlose T g about 120°C Amorphous trehalose can be obtained by quenching of the melt or by milling of the #-form but not by milling of the dihydrate Amorphous treahlose dihydrate T g about 20°C

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British Library EThOS: Cryomilling for formulation

Phthalic acid, isophthalic acid and terephthalic acid, individual and pair mixtures, are crystalline organic non medicinal compounds, which have been used for the first time as model compounds to investigate whether cryogenic milling can induce crystal to amorphous transformation and if the preparation of pair mixtures could affect the ...

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cost of cryogenic grinding - ezikorestaurant

Home Milling Grinding cryogenic fine mill cost, air products showcases polarfit, retsch cryogenic jar mill retsch cryogenic mill from cole parmer. Free Quote. cryogenic fine mill cost. Belt Conveyor. Mining delivers the world's most comprehensive range of Heavy-duty conveyor belts. Base on more than 30 years of experience in development . Get Price

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Making Amorphous API - ICDD

Making Amorphous API Ann Newman Seventh Street Development Group PO Box 526, Lafayette, IN 47902 765-650-4462 ... • Trehalose –Three known forms: dihydrate, anhydrate, amorphous –Form obtained upon drying dihydrate depends on particle size, rate, drying conditions .

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Polymorphic Amorphous and Crystalline Forms of Trehalose ...

A characterization has been carried out on the dihydrate and anhydrous crystalline form of trehalose (α-d-Glucopyranosyl-α-d-glucopyranoside), which is considered anomalous in respect to other disaccharides in conferring to organisms the ability to be dried at high temperatures and then to rehydrate without damaging cellular functions. The thermal dehydration of the dihydrate trehalose, Th ...

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Raman Spectroscopy - University of Nottingham

Raman spectroscopy is a non-invasive optical technique used to determine the chemical identity and state of a sample by its unique vibrational (molecular) modes. Inelastic (loss or gain of energy) scattering of light from the sample is measured, with distinct shifts in the energy of the scattered photons being representative of the sample ...

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Amorphous trehalose dihydrate by cryogenic milling | A.J ...

Trehalose dihydrate is a safe, naturally occurring disaccharide used as a food ingredient and pharmaceutical excipient. It has been reported that room temperature milling does not lead to the ...

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WO1997028788A1 - Solid formulations containing trehalose ...

A method of making solid dosage forms comprises the steps of: a) combining components comprising an amount of trehalose sufficient to act as an effective diluent in the tablets formed and an amount of an active agent such that each dosage form formed contains an effective amount of active agent and an amount of aqueous solvent sufficient to suspend or dissolve the trehalose and active agent; b ...

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Amorphous Solids - icdd

Amorphous Solids Lian Yu University of Wisconsin – Madison School of Pharmacy and Department of ... milling, and other processes • Occasionally the "only" solid form available. ... amorphous solids: Trehalose dihydrate. Willart et al., Solid State Comm. 119 .

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Amorphous Solids - icdd

Amorphous Solids Lian Yu University of Wisconsin – Madison School of Pharmacy and Department of ... milling, and other processes • Occasionally the "only" solid form available. ... amorphous solids: Trehalose dihydrate. Willart et al., Solid State Comm. 119 .

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Characterization of the phase transitions of trehalose ...

Characterization of the phase transitions of trehalose dihydrate on heating and subsequent dehydration. Authors. Lynne S. Taylor, ... Amorphous trehalose dihydrate by cryogenic milling, Carbohydrate Research, 2011, 346, 8, 1061CrossRef;

  • Published in: Journal of Pharmaceutical Sciences · 1998Authors: Lynne S Taylor · Peter YorkAffiliation: University of BradfordAbout: Hydrate · Phase transition · Particle size · Trehalose · X-ray crystallography · Dehydra.Get Price
Estimation of crystallinity of trehalose dihydrate ...

Sep 01, 2012 · Read "Estimation of crystallinity of trehalose dihydrate microspheres by usage of terahertz time‐domain spectroscopy, Journal of Pharmaceutical Sciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at .

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Amorphous trehalose dihydrate by cryogenic milling ...

Jun 01, 2011 · It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy.

Polymorphic Amorphous and Crystalline Forms of Trehalose ...

A characterization has been carried out on the dihydrate and anhydrous crystalline form of trehalose (α-d-Glucopyranosyl-α-d-glucopyranoside), which is considered anomalous in respect to other disaccharides in conferring to organisms the ability to be dried at high temperatures and then to rehydrate without damaging cellular functions. The thermal dehydration of the dihydrate trehalose, Th ...

D-(+)-Trehalose dihydrate | CAS#:6138-23-4 | Chemsrc

SUMO1 promotes Aβ production via the modulation of autophagy. Autophagy 11(1), 100-12, (2015) Autophagy is one of the main mechanisms in the pathophysiology of neurodegenerative disease.

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Technical Cost Modeling for the Mechanical Milling at ...

It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at ...

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